Glycoconjugate vaccines: current approaches towards faster vaccine design
نویسندگان
چکیده
منابع مشابه
New approaches to glycoconjugate synthesis
Absnuct: Generally convergent strategies are employed in glyconjugate synthesis, hence the oligosaccharide moiety and the aglycon moiety are separately prepared and then linked to yield the target molecule; for glycopeptides linear synthesis strategies are more successful. The importance of p-glycosidic linkages of glucosamine and galactosamine in glycoconjugates was reason for the development ...
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Nontyphoidal salmonellae, particularly Salmonella enterica serovar Typhimurium, are a major cause of invasive disease in Africa, affecting mainly young children and HIV-infected individuals. Glycoconjugate vaccines provide a safe and reliable strategy against invasive polysaccharide-encapsulated pathogens, and lipopolysaccharide (LPS) is a target of protective immune responses. With the aim of ...
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• Modified peptides: these molecules contain relatively small modifications that do not modify the peptide bond, and thus they still possess a chemical structure of peptide nature. • Pseudopeptides: in these compounds partial modifications of either peptide bonds or side-chains are introduced, contributing to the generation of molecules possessing a chemical structure of only partial peptide na...
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Production of glycoconjugate vaccines involves the chemical conjugation of glycans to an immunogenic carrier protein such as Cross-Reactive-Material-197 (CRM197). Instead of using glycans from natural sources recent vaccine development has been focusing on the use of synthetically defined minimal epitopes. While the glycan is structurally defined, the attachment sites on the protein are not. Fu...
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Many pathogens are sheltered from host immunity by surface polysaccharides that would be ideal as vaccines except that they are too similar to host antigens to be immunogenic. The production of functional IgG is a desirable response to vaccines; because IgG is the only isotype that crosses the placenta, it is of particular importance in maternal vaccines against neonatal disease due to group B ...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2019
ISSN: 1476-0584,1744-8395
DOI: 10.1080/14760584.2019.1657012